Entropion, severe dry eye and trichiasis (inturning of eyelashes) may cause ulceration of the peripheral cornea. The topical prednisolone was continued for a month in tapering dosage and replaced by a milder steroid i.e. In one open-label, randomized, controlled, multicenter clinical trial which enrolled 164 patients with herpetic keratitis, Zirgan was non-inferior to acyclovir ophthalmic ointment, 3% in patients with dendritic ulcers. Zirgan will be supplied in a 5 gram tube and will be available by prescription through retail pharmacies. At the time of initial infection, HSV-1 travels to the neural ganglion and becomes latent, conferring a lifetime infection. Symptoms of raised intraocular pressure are deep eye pain (described as throbbing, drilling pain), redness, blurred vision (often with haloes around lights due to corneal oedema), headache, nausea and vomiting.